As Ghana’s petroleum industry approaches a decade of local content development, novel techniques are vital to rejuvenate exploration and sustain the industry. This presentation delves into how machine learning, a pivotal facet of big data, is revolutionizing geophysical exploration globally. By marrying industry with academia, we can leverage machine learning to uncover untapped petroleum reserves in Ghana, bridging research and practical application for cost-effective discoveries. Our case studies elucidate the transformative power of this union in charting the next decade of Ghana’s upstream potential.